Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61620

TitleAssociation of the gene encoding neurogranin with schizophrenia in males
Author(s)Ruano, Dina
Aulchenko, Yurii S.
Macedo, António
Soares, Maria J.
Valente, José
Azevedo, Maria H.
Hutz, Mara H.
Gama, Clarissa S.
Lobato, Maria I.
Belmonte-de-Abreu, Paulo
Goodman, Ann B.
Pato, Carlos
Heutink, Peter
Palha, Joana Almeida
KeywordsAge of Onset
Azores
Brazil
Case-Control Studies
Exons
Gene Frequency
Gene Pool
Genetic Carrier Screening
Genetic Markers
Genetics, Population
Genotype
Humans
Introns
Linkage Disequilibrium
Male
Neurogranin
Nucleotides
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Portugal
Schizophrenia
association studies
thyroid hormone
retinoids
glutamate
Issue dateJan-2008
PublisherElsevier
JournalJournal of Psychiatric Research
CitationRuano, D., Aulchenko, Y. S., Macedo, A., Soares, M. J., Valente, J., Azevedo, M. H., ... & Goodman, A. B. (2008). Association of the gene encoding neurogranin with schizophrenia in males. Journal of psychiatric research, 42(2), 125-133.
Abstract(s)The neurogranin (NRGN) gene produces a postsynaptic brain-specific protein that regulates calmodulin-Ca(2+) availability in neurons. Acting downstream of the NMDA receptor and upstream of calcineurin and other proteins implicated in schizophrenia, NRGN is a good candidate for association studies in schizophrenia. NRGN expression is regulated during development and is modulated by thyroid hormones and retinoids, molecules essential for the proper development of the central nervous system. Given the genetic complexity of schizophrenia and the potential genetic heterogeneity in different populations, we studied a possible association of NRGN with schizophrenia in 73 Azorean proband-parent triads and in two independent case-control samples from the Portuguese-mainland (244 schizophrenic and 210 controls) and Brazil (69 schizophrenic and 85 mentally healthy individuals). Genotype distribution showed association of the rs7113041 SNP with schizophrenia in males of Portuguese origin, which was confirmed by the analysis of the proband-parent triads. This evidence, implicating NRGN in schizophrenia, introduces another player into the glutamatergic hypothesis of schizophrenia.
TypeArticle
URIhttp://hdl.handle.net/1822/61620
DOI10.1016/j.jpsychires.2006.10.008
ISSN0022-3956
e-ISSN1879-1379
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0022395606002135
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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