Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61614

TitleIncreased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
Author(s)Pinheiro, Céline
Longatto, Adhemar
Scapulatempo, Cristovam
Ferreira, Luísa
Martins, Sandra
Pellerin, Luc
Rodrigues, Mesquita
Alves, Venâncio A. F.
Schmitt, Fernando
Baltazar, Fátima
KeywordsMonocarboxylate transporter
Colorectal carcinoma
Issue date2008
PublisherSpringer-Verlag Berlin
JournalVirchows Archiv
CitationPinheiro, C., Longatto-Filho, A., Scapulatempo, C., Ferreira, L., Martins, S., Pellerin, L., ... & Baltazar, F. (2008). Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Archiv, 452(2), 139-146.
Abstract(s)Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy
TypeArticle
URIhttp://hdl.handle.net/1822/61614
DOI10.1007/s00428-007-0558-5
ISSN0945-6317
e-ISSN1432-2307
Publisher versionhttps://link.springer.com/article/10.1007/s00428-007-0558-5
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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