Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61481
Título: | Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy |
Autor(es): | Pereira, Daniela S. M. Cardoso, Beatriz D. Rodrigues, Ana Rita O. Amorim, Carlos O. Amaral, Vítor S. Almeida, B. G. Queiroz, Maria João R. P. Martinho, Olga Baltazar, Fátima Calhelha, Ricardo C. Ferreira, Isabel C. F. R. Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
Palavras-chave: | calcium ferrite nanoparticles magnetoliposomes new antitumor drugs thienopyridine derivatives breast cancer therapy |
Data: | 2019 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Pharmaceutics |
Citação: | Pereira, D.S.M.; Cardoso, B.D.; Rodrigues, A.R.O.; Amorim, C.O.; Amaral, V.S.; Almeida, B.G.; Queiroz, M.-J.; Martinho, O.; Baltazar, F.; Calhelha, R.C.; Ferreira, I.C.F.R.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy. Pharmaceutics 2019, 11, 477. |
Resumo(s): | Magnetoliposomes containing calcium ferrite (CaFe<sub>2</sub>O<sub>4</sub>) nanoparticles were developed and characterized for the first time. CaFe<sub>2</sub>O<sub>4 </sub>nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 ± 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation efficiencies (70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61481 |
DOI: | 10.3390/pharmaceutics11090477 |
ISSN: | 1999-4923 |
Versão da editora: | https://www.mdpi.com/1999-4923/11/9/477 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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pharmaceutics-11-00477-v2.pdf | 3,64 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons