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https://hdl.handle.net/1822/61477
Título: | Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers |
Autor(es): | Longatto, Adhemar Pinheiro, Céline Ferreira, Luísa Scapulatempo, Cristovam Alves, Venancio A. F. Baltazar, Fátima Schmitt, Fernando |
Palavras-chave: | Adenocarcinoma Adult Aged Aged, 80 and over Biomarkers, Tumor Colorectal Neoplasms Female Humans Immunoenzyme Techniques Liver Neoplasms Lymphatic Vessels Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis D2-40 colorectal carcinoma metastasis lymphatic vessel density lymphatic invasion lymph-node invasion |
Data: | Fev-2008 |
Editora: | Springer |
Revista: | Virchows Archiv |
Citação: | Longatto-Filho, A., Pinheiro, C., Ferreira, L., Scapulatempo, C., Alves, V. A., Baltazar, F., & Schmitt, F. (2008). Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Virchows Archiv, 452(2), 133-138. |
Resumo(s): | To evaluate whether lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) are useful markers of worse outcome in colorectal carcinoma and if LVD and LVI correlate to the classical clinical-pathological parameters, we analysed 120 cases of colorectal carcinomas selected from the files of Division of Pathology, Hospital das Clinicas, São Paulo University, Brazil. Assessment of LVD and LVI was performed by immunohistochemical detection of lymphatic vessels, using the monoclonal antibody D2-40. Higher LVD was found in the intratumoural area, when comparing with normal and peritumoural areas (p < 0.001). However, peritumoural LVD, but not intratumoural, correlated with both colonic-wall-invasion depth (p = 0.037) and liver metastasis (p = 0.012). Remarkably, LVI was found associated with local invasion (p = 0.016), nodal metastasis (p = 0.022) and hepatic metastasis (p < 0.001). Peritumoural LVD and LVI are directly related to histopathological variables indicative of poor outcome such as lymph-node status and liver metastasis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61477 |
DOI: | 10.1007/s00428-007-0550-0 |
ISSN: | 0945-6317 |
e-ISSN: | 1432-2307 |
Versão da editora: | https://link.springer.com/article/10.1007/s00428-007-0550-0 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Longatto-filho-2008-Peritumoural-but-not-intratumoural-.pdf | 153,27 kB | Adobe PDF | Ver/Abrir |