Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61477

TitlePeritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers
Author(s)Longatto, Adhemar
Pinheiro, Céline
Ferreira, Luísa
Scapulatempo, Cristovam
Alves, Venancio A. F.
Baltazar, Fátima
Schmitt, Fernando
KeywordsAdenocarcinoma
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Colorectal Neoplasms
Female
Humans
Immunoenzyme Techniques
Liver Neoplasms
Lymphatic Vessels
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
D2-40
colorectal carcinoma
metastasis
lymphatic vessel density
lymphatic invasion
lymph-node invasion
Issue dateFeb-2008
PublisherSpringer
JournalVirchows Archiv
CitationLongatto-Filho, A., Pinheiro, C., Ferreira, L., Scapulatempo, C., Alves, V. A., Baltazar, F., & Schmitt, F. (2008). Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Virchows Archiv, 452(2), 133-138.
Abstract(s)To evaluate whether lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) are useful markers of worse outcome in colorectal carcinoma and if LVD and LVI correlate to the classical clinical-pathological parameters, we analysed 120 cases of colorectal carcinomas selected from the files of Division of Pathology, Hospital das Clinicas, São Paulo University, Brazil. Assessment of LVD and LVI was performed by immunohistochemical detection of lymphatic vessels, using the monoclonal antibody D2-40. Higher LVD was found in the intratumoural area, when comparing with normal and peritumoural areas (p < 0.001). However, peritumoural LVD, but not intratumoural, correlated with both colonic-wall-invasion depth (p = 0.037) and liver metastasis (p = 0.012). Remarkably, LVI was found associated with local invasion (p = 0.016), nodal metastasis (p = 0.022) and hepatic metastasis (p < 0.001). Peritumoural LVD and LVI are directly related to histopathological variables indicative of poor outcome such as lymph-node status and liver metastasis.
TypeArticle
URIhttp://hdl.handle.net/1822/61477
DOI10.1007/s00428-007-0550-0
ISSN0945-6317
e-ISSN1432-2307
Publisher versionhttps://link.springer.com/article/10.1007/s00428-007-0550-0
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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