Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61458

TitleThe stressed prefrontal cortex. Left? Right!
Author(s)Cerqueira, João José
Almeida, Osborne F. X.
Sousa, Nuno
KeywordsAdaptation, Psychological
Animals
Functional Laterality
Humans
Hypothalamo-Hypophyseal System
Neurosecretory Systems
Paraventricular Hypothalamic Nucleus
Pituitary-Adrenal System
Prefrontal Cortex
Stress, Psychological
HPA axis
Hippocampus
Handedness
Hemispheric asymmetry
Lateralization
Immune response
Autonomic nervous system
stress
Issue dateJul-2008
PublisherElsevier
JournalBrain, Behavior, and Immunity
Abstract(s)The prefrontal cortex (PFC) plays an important role in the integration of cognitive and affective behavior and regulating autonomic and neuroendocrine functions. This region of the brain, which may be considered analogous to the RAM memory of a computer, is important for translating stressful experience into adaptive behavior. The PFC responds to stress and modulates the response to stress through regulation of the hypothalamic paraventricular nucleus (PVN) which, in turn, controls sympathoadrenal and hypothalamic-pituitary-adrenal (HPA) activity. Interestingly, the latter convey the signals that link the CNS with the immune system. The present review highlights findings that contribute to elucidate the involvement of the PFC in the control of behavioral and neuroendocrine responses to chronic stress. It also considers the implications of these regulatory links for disorders of the nervous and immune systems.
TypeArticle
URIhttp://hdl.handle.net/1822/61458
DOI10.1016/j.bbi.2008.01.005
ISSN0889-1591
e-ISSN1090-2139
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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