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TitleGeneration of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease
Author(s)Savchenko, Ekaterina
Marote, Ana
Russ, Kaspar
Collin, Anna
Goldwurm, Stefano
Roybon, Laurent
Pomeshchik, Yuriy
Cell Differentiation
Cells, Cultured
Germ Layers
Induced Pluripotent Stem Cells
Parkinson Disease
Issue date2018
PublisherElsevier Science BV
JournalStem Cell Research
Abstract(s)Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder.
TypeJournal editorial
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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