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https://hdl.handle.net/1822/59944| Título: | Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease |
| Autor(es): | Savchenko, Ekaterina Marote, Ana Maria Franco Aveiro Russ, Kaspar Collin, Anna Goldwurm, Stefano Roybon, Laurent Pomeshchik, Yuriy |
| Palavras-chave: | Adult Cell Differentiation Cells, Cultured Female Fibroblasts Germ Layers Humans Induced Pluripotent Stem Cells Karyotype Parkinson Disease |
| Data: | 2018 |
| Editora: | Elsevier Science BV |
| Revista: | Stem Cell Research |
| Resumo(s): | Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/59944 |
| DOI: | 10.1016/j.scr.2018.01.002 |
| ISSN: | 1873-5061 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Savchenko. CSC42.pdf | 1,35 MB | Adobe PDF | Ver/Abrir |
