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https://hdl.handle.net/1822/59782
Título: | Predictors of residual T1 high grade on re-transurethral resection in a large multi-institutional cohort of patients with primary T1 high-grade/grade 3 bladder cancer |
Autor(es): | Ferro, Matteo Di Lorenzo, Giuseppe Buonerba, Carlo Lucarelli, Giuseppe Russo, Giorgio Ivan Cantiello, Francesco Farhan, Abdal Rahman Abu Di Stasi, Savino Musi, Gennaro Hurle, Rodolfo Vincenzo, Serretta Busetto, Gian Maria De Berardinis, Ettore Perdonà, Sisto Borghesi, Marco Schiavina, Riccardo Almeida, Gilberto L Bove, Pierluigi Lima, Estêvão Augusto Rodrigues de Grimaldi, Giovanni Matei, Deliu Victor Mistretta, Francesco Alessandro Crisan, Nicolae Terracciano, Daniela Paolo, Verze Battaglia, Michele Guazzoni, Giorgio Autorino, Riccardo Morgia, Giuseppe Damiano, Rocco Muto, Matteo Rocca, Roberto La Mirone, Vincenzo de Cobelli, Ottavio Vartolomei, Mihai Dorin |
Palavras-chave: | bladder cancer neutrophil-to-lymphocytes ratio re-transurethral resection high-grade |
Data: | 2018 |
Editora: | Ivyspring International Publisher |
Revista: | Journal of Cancer |
Resumo(s): | The aim of this multi-institutional study was to identify predictors of residual high-grade (HG) disease at re-transurethral resection (reTUR) in a large cohort of primary T1 HG/Grade 3 (G3) bladder cancer patients. A total of 1155 patients with primary T1 HG/G3 bladder cancer from 13 academic institutions that underwent a reTUR within 6 weeks after first TUR were evaluated. Logistic regression analysis was performed to assess the association of predictive factors with residual HG at reTUR. Residual HG cancer was found in 288 (24.9%) of patients at reTUR. Patients presenting residual HG cancer were more likely to have carcinoma in situ (CIS) at first resection (p<0.001), multiple tumors (p=0.02), and tumor size larger than 3 cm (p=0.02). Residual HG disease at reTUR was associated with increased preoperative neutrophil-to-lymphocytes ratio (NLR) (p=0.006) and body mass index (BMI)>=25 kg/m2. On multivariable analysis, independent predictors for HG residual disease at reTUR were tumor size >3cm (OR = 1.37; 95% CI: 1.02-1.84, p=0.03), concomitant CIS (OR 1.92; 95% CI: 1.32-2.78, p=0.001), being overweight (OR= 2.08; 95% CI: 1.44-3.01, p<0.001) and obesity (OR 2.48; 95% CI: 1.64-3.77, p<0.001). A reTUR in high grade T1 bladder cancer is mandatory as about 25% of patients, presents residual high grade disease. Independent predictors to identify patients at risk of residual high grade disease after a complete TUR include tumor size, presence of carcinoma in situ, and BMI >=25 kg/m2. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/59782 |
DOI: | 10.7150/jca.26129 |
ISSN: | 1837-9664 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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FerroE2018.pdf Acesso restrito! | 267,84 kB | Adobe PDF | Ver/Abrir |