Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58829
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Leite, Álvaro J. | por |
dc.contributor.author | Oliveira, Nuno M. | por |
dc.contributor.author | Song, W. | por |
dc.contributor.author | Mano, J. F. | por |
dc.date.accessioned | 2019-01-31T16:43:24Z | - |
dc.date.available | 2019-01-31T16:43:24Z | - |
dc.date.issued | 2018-10 | - |
dc.date.submitted | 2018-02 | - |
dc.identifier.citation | Leite A. J., Oliveira N. M., Song W., Mano J. F. Bioactive Hydrogel Marbles, Scientific Reports, Vol. 8, Issue 15215, pp. 1-11, doi:10.1038/s41598-018-33192-6, 2018 | por |
dc.identifier.issn | 2045-2322 | por |
dc.identifier.uri | https://hdl.handle.net/1822/58829 | - |
dc.description.abstract | Liquid marbles represented a signifcant advance in the manipulation of fuids as they used particle flms to confne liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifcally, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efcient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering. | por |
dc.description.sponsorship | Portuguese Foundation for Science and Technology − FCT (Grant Nos SFRH/BD/73174/2010 and SFRH/BD/73172/2010, respectively), from the program POPH/FSE from QREN. The authors would like to acknowledge the support of the European Research Council grant agreement ERC-2014-ADG-669858 for project ATLAS | por |
dc.language.iso | eng | por |
dc.publisher | Nature Research | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73174%2F2010/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73172%2F2010/PT | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/669858/EU | - |
dc.rights | openAccess | por |
dc.subject | Bioactive nanoparticles | por |
dc.subject | Hydrogel | por |
dc.subject | Marbles | por |
dc.title | Bioactive Hydrogel Marbles | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-018-33192-6 | por |
dc.comments | http://3bs.uminho.pt/node/19749 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 11 | por |
oaire.citationIssue | 15215 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2019-01-31T15:10:41Z | - |
dc.identifier.eissn | 2045-2322 | por |
dc.identifier.doi | 10.1038/s41598-018-33192-6 | por |
dc.identifier.pmid | 30315183 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.fos | Engenharia e Tecnologia::Biotecnologia Industrial | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Scientific Reports | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19749-ALeite-ScientificReports 2018.pdf | 1,76 MB | Adobe PDF | Ver/Abrir |