Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58829
Título: | Bioactive Hydrogel Marbles |
Autor(es): | Leite, Álvaro J. Oliveira, Nuno M. Song, W. Mano, J. F. |
Palavras-chave: | Bioactive nanoparticles Hydrogel Marbles |
Data: | Out-2018 |
Editora: | Nature Research |
Revista: | Scientific Reports |
Citação: | Leite A. J., Oliveira N. M., Song W., Mano J. F. Bioactive Hydrogel Marbles, Scientific Reports, Vol. 8, Issue 15215, pp. 1-11, doi:10.1038/s41598-018-33192-6, 2018 |
Resumo(s): | Liquid marbles represented a signifcant advance in the manipulation of fuids as they used particle flms to confne liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifcally, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efcient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58829 |
DOI: | 10.1038/s41598-018-33192-6 |
ISSN: | 2045-2322 |
e-ISSN: | 2045-2322 |
Versão da editora: | https://www.nature.com/articles/s41598-018-33192-6 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19749-ALeite-ScientificReports 2018.pdf | 1,76 MB | Adobe PDF | Ver/Abrir |