Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58782

TitleMetabolic regulation of innate immunity to fungal infection
Author(s)Rodrigues, Cláudia S.
Campos, Cláudia F.
Cunha, Cristina
Carvalho, Agostinho
KeywordsEpigenetics
Fungal disease
Immunometabolism
Trained immunity
β-glucan
Issue date2018
JournalExperientia Supplementum
Abstract(s)In recent years, the renewed interest in immune cell metabolism has driven the emergence of a research field aimed at studying the role of metabolic processes during innate and adaptive immune responses. Although the specific requirements of myeloid cells after the canonical lipopolysaccharide/TLR4 stimulation have been extensively addressed, recent evidence suggests that this model may not represent a universally accurate metabolic blueprint. Instead, different microbial stimuli, pathogens, or tissue microenvironments trigger specific and complex metabolic rewiring of myeloid cells. This chapter aims to provide an overview of the metabolic heterogeneity in activated myeloid cells during fungal disease. Directions for future research in dissecting the uniqueness of metabolic signatures during fungal infection are suggested to ultimately provide new tailored diagnostic and therapeutic interventions.
TypeArticle
URIhttp://hdl.handle.net/1822/58782
DOI10.1007/978-3-319-74932-7_11
ISSN1664-431X
AccessRestricted access (Author)
Appears in Collections:ICVS - Livros e Capítulos de Livros

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