Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58779

TitleMetabolic host response to intracellular infections
Author(s)Ferreira, Catarina Machado
Barbosa, Ana Margarida Martins
Pereira, Inês M.
Torrado, Egídio
KeywordsHost-pathogen interactions
Immunity
Infection
Intracellular bacteria
Metabolism
Issue date2018
JournalExperientia Supplementum
Abstract(s)The interaction between intracellular bacterial pathogens with the host immune response can result in multiple outcomes that range from asymptomatic clearance to the establishment of infection. At its core, these interactions result in multiple metabolic adaptations of both the pathogen and its host cell. There is growing evidence that the host metabolic response plays a key role in the development of immune responses against the invading pathogen. However, successful intracellular pathogens have developed multiple mechanisms to circumvent the host response to thrive in the intracellular compartment. Here, we provide a brief overview on the crucial role of fundamental metabolic host responses in the generation of protective immunity to intracellular bacterial pathogens and discuss some of the mechanisms used by these pathogens to exploit the host metabolic response to their own advantage. This understanding will further our knowledge in host-pathogen interactions and may provide new insights for the development of novel therapies.
TypeArticle
URIhttp://hdl.handle.net/1822/58779
DOI10.1007/978-3-319-74932-7_8
ISSN1664-431X
AccessRestricted access (Author)
Appears in Collections:ICVS - Livros e Capítulos de Livros

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