Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58275
Título: | Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
Autor(es): | Arieira, Cátia Castro, Francisca Dias de Moreira, Maria João Cotter, José Almeida Berkeley |
Palavras-chave: | Biological therapy Common variable immunodeficiency Crohn disease Inflammatory bowel disease Infliximab Small bowel capsule endoscopy |
Data: | Nov-2018 |
Editora: | Karger Publishers |
Revista: | GE Portuguese Journal of Gastroenterology |
Resumo(s): | Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day was started, but no positive clinical response was observed. It was decided to initiate biological therapy with infliximab. The patient's condition is currently clinically improved with no complications due to biological therapy. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58275 |
DOI: | 10.1159/000486448 |
ISSN: | 2341-4545 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Arieira.pdf | 940,61 kB | Adobe PDF | Ver/Abrir |