Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58202
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Campo DC | Valor | Idioma |
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dc.contributor.author | Moron, Roberson A. | por |
dc.contributor.author | Jacob, Carlos Eduardo | por |
dc.contributor.author | Bresciani, Claudio José Caldas | por |
dc.contributor.author | Simões, Kleber | por |
dc.contributor.author | Alves, Venâncio Avancini Ferreira | por |
dc.contributor.author | Irya, Kyoshi | por |
dc.contributor.author | Gama-Rodrigues, Joaquim | por |
dc.contributor.author | Cecconello, Ivan | por |
dc.contributor.author | Longatto, Adhemar | por |
dc.contributor.author | Zilberstein, Bruno | por |
dc.date.accessioned | 2019-01-15T11:55:35Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | Moron, R. A., Jacob, C. E., Bresciani, C. J. C., Simões, K., Alves, V. A. F., Irya, K., ... & Zilberstein, B. (2018). Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma. Molecular and Clinical Oncology, 8(3), 477-482. | por |
dc.identifier.issn | 2049-9450 | - |
dc.identifier.uri | https://hdl.handle.net/1822/58202 | - |
dc.description.abstract | The aim of the present study was to determine the clinical significance of p53 and p21ras p21wafl, p27kip1 and p16ink4a expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21ras, p53, p21waf1/cip1, p27kip1 and p16ink4a in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively. In the same tissues, p21ras was positivE in 85.3, 86 and 96.8%, respectively. Positivity FOR p16ink4a was DETECTED IN 46.3, 91.1 and 86% OF THE CASES, respectively, WHEREAS p27kip1 WAS positiVE IN 60, 94.7 and 95.3%, and p21wafl/cip1 WAS positivE IN 32.4, 72.7 and 71.4% OF THE CASES, respectively. All THE tumors WERE positive for p53. Tumors with lymph node invasion presented WITH OVERexpression (+4) of p53 in 47% of the cases VS. 17% OF patients who DID not HAVE lymph node involvement. THEREFORE, higher expression of p53, p21ras and p21wafl/cip1 IN the tumor exhibited a statistically significant association with lymph node involvement. | por |
dc.language.iso | eng | por |
dc.publisher | Spandidos Publications | por |
dc.rights | openAccess | - |
dc.subject | gastric cancer | por |
dc.subject | p21(ras) | por |
dc.subject | p53 | por |
dc.subject | p21(waf1/cip1) | por |
dc.subject | p27(kip1) | por |
dc.subject | p16(ink4a) | por |
dc.title | Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.spandidos-publications.com/mco/8/3/477 | por |
oaire.citationStartPage | 477 | por |
oaire.citationEndPage | 482 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 8 | por |
dc.identifier.eissn | 2049-9469 | - |
dc.identifier.doi | 10.3892/mco.2017.1545 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Molecular and Clinical Oncology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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moron 2018.pdf | 300,26 kB | Adobe PDF | Ver/Abrir |