Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58088

TitlePresence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus
Author(s)Campanella, Nathália C.
Lacerda, Croider Franco
Berardinelli, Gustavo Noriz
Abrahão-Machado, Lucas Faria
Cruvinel-Carloni, Adriana
De Oliveira, Antônio Talvane Torres
Scapulatempo-Neto, Cristovam
Crema, Eduardo
Adad, Sheila Jorge
Rodrigues, Maria Aparecida Marchesan
Henry, Maria Aparecida Coelho Arruda
Guimarães, Denise Peixoto
Reis, R. M.
KeywordsChagas disease
Chagasic megaesophagus
Esophageal squamous cell carcinoma
HSP10
Microsatellite instability
Mismatch repair
MSH6
Issue dateJun-2018
PublisherFuture Medicine
JournalBiomarkers in Medicine
CitationCampanella, N. C., Lacerda, C. F., Berardinelli, G. N., Abrahão-Machado, L. F., Cruvinel-Carloni, A., et. al.(2018). Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus. Biomarkers in medicine, (0)
Abstract(s)The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene.
TypeArticle
URIhttp://hdl.handle.net/1822/58088
DOI10.2217/bmm-2017-0329
ISSN1752-0363
e-ISSN1752-0371
Publisher versionhttps://www.futuremedicine.com/doi/abs/10.2217/bmm-2017-0329
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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