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https://hdl.handle.net/1822/58088
Título: | Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus |
Autor(es): | Campanella, Nathália C. Lacerda, Croider Franco Berardinelli, Gustavo Noriz Abrahão-Machado, Lucas Faria Cruvinel-Carloni, Adriana De Oliveira, Antônio Talvane Torres Scapulatempo-Neto, Cristovam Crema, Eduardo Adad, Sheila Jorge Rodrigues, Maria Aparecida Marchesan Henry, Maria Aparecida Coelho Arruda Guimarães, Denise Peixoto Reis, R. M. |
Palavras-chave: | Chagas disease Chagasic megaesophagus Esophageal squamous cell carcinoma HSP10 Microsatellite instability Mismatch repair MSH6 |
Data: | Jun-2018 |
Editora: | Future Medicine |
Revista: | Biomarkers in Medicine |
Citação: | Campanella, N. C., Lacerda, C. F., Berardinelli, G. N., Abrahão-Machado, L. F., Cruvinel-Carloni, A., et. al.(2018). Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus. Biomarkers in medicine, (0) |
Resumo(s): | The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58088 |
DOI: | 10.2217/bmm-2017-0329 |
ISSN: | 1752-0363 |
e-ISSN: | 1752-0371 |
Versão da editora: | https://www.futuremedicine.com/doi/abs/10.2217/bmm-2017-0329 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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campanella2018.pdf Acesso restrito! | 3,97 MB | Adobe PDF | Ver/Abrir |