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TitlePresence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus
Author(s)Campanella, Nathália C.
Lacerda, Croider Franco
Berardinelli, Gustavo Noriz
Abrahão-Machado, Lucas Faria
Cruvinel-Carloni, Adriana
De Oliveira, Antônio Talvane Torres
Scapulatempo-Neto, Cristovam
Crema, Eduardo
Adad, Sheila Jorge
Rodrigues, Maria Aparecida Marchesan
Henry, Maria Aparecida Coelho Arruda
Guimarães, Denise Peixoto
Reis, R. M.
KeywordsChagas disease
Chagasic megaesophagus
Esophageal squamous cell carcinoma
Microsatellite instability
Mismatch repair
Issue dateJun-2018
PublisherFuture Medicine
JournalBiomarkers in Medicine
CitationCampanella, N. C., Lacerda, C. F., Berardinelli, G. N., Abrahão-Machado, L. F., Cruvinel-Carloni, A., et. al.(2018). Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus. Biomarkers in medicine, (0)
Abstract(s)The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene.
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Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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