Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58060
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Miranda, Margarida Silva | por |
dc.contributor.author | Rodrigues, Márcia T. | por |
dc.contributor.author | Domingues, Rui Miguel Andrade | por |
dc.contributor.author | Costa, Rui R. | por |
dc.contributor.author | Paz, Elvira | por |
dc.contributor.author | Rodríguez-Abreu, Carlos | por |
dc.contributor.author | Freitas, Paulo | por |
dc.contributor.author | Almeida, B. G. | por |
dc.contributor.author | Carvalho, M. Alice | por |
dc.contributor.author | Gonçalves, Carine Machado | por |
dc.contributor.author | Ferreira, Catarina Machado | por |
dc.contributor.author | Torrado, Egídio | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Pedrosa, Jorge | por |
dc.contributor.author | Gomes, Manuela E. | por |
dc.date.accessioned | 2019-01-11T12:24:29Z | - |
dc.date.available | 2019-09-01T06:00:53Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://hdl.handle.net/1822/58060 | - |
dc.description.abstract | Tuberculosis (TB) is an infectious disease which affects millions of people worldwide. Inhalable polymeric dry powders are promising alternatives as anti-TB drug carriers to the alveoli milieu and infected macrophages, with potential to significantly improve the therapeutics efficiency. Here, the development of a magnetically responsive microparticulate system for pulmonary delivery of an anti-TB drug candidate (P3) is reported. Microparticles (MPs) are developed based on a cast method using calcium carbonate sacrificial templates and incorporate superparamagnetic iron oxide nanoparticles to concentrate MPs in alveoli and enable drug on demand release upon actuation of an external alternate magnetic field (AMF). The MPs are shown to be suitable for P3 delivery to the lower airways and for alveolar macrophage phagocytosis. The developed MPs reveal unique and promising features to be used as an inhalable dry powder allowing the AMF control over dosage and frequency of drug delivery anticipating improved TB treatments. | por |
dc.description.sponsorship | The authors wish to acknowledge the financial support from the Portuguese Foundation for Science and Technology (FCT) for the postdoctoral grant of M.S.M. (SFRH/BPD/110868/2015) and R.M.A.D (SFRH/BPD/112459/2015), FCT grant of E.T. (IF/01390/2014) and Recognize project (UTAP-ICDT/CTM-BIO/0023/2014). This article is also a result of the project “Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechnologies, marine-derived biomaterials and stem cells,” supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The authors acknowledge the financial support from the European Union Framework Programme for Research and Innovation HORIZON 2020, under the TEAMING Grant Agreement No. 739572 – The Discoveries CTR. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/137422/PT | por |
dc.rights | openAccess | por |
dc.subject | Biomaterials | por |
dc.subject | Inhalable dry powders | por |
dc.subject | Magnetic drug targeting | por |
dc.subject | Microparticulate systems | por |
dc.subject | Remotely controlled drug release | por |
dc.title | Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in microparticulate system for antituberculosis drug delivery | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | e1800124-1 | por |
oaire.citationEndPage | e1800124-12 | por |
oaire.citationIssue | 15 | por |
oaire.citationVolume | 7 | por |
dc.identifier.eissn | 2192-2659 | - |
dc.identifier.doi | 10.1002/adhm.201800124 | por |
dc.identifier.pmid | 29797461 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Healthcare Materials | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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DEVELO~1.PDF | 1,89 MB | Adobe PDF | Ver/Abrir |