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TitleMetals(loids) targeting fish eyes and brain in a contaminated estuary - Uncovering neurosensory (un)susceptibility through bioaccumulation, antioxidant and morphometric profiles
Author(s)Pereira, Ricardo
Leite, Eduarda
Raimundo, Joana
Guilherme, Sofia
Puga, Sónia Andreia Silva
Pinto-Ribeiro, Filipa
Santos, Maria Ana
Canário, João
Almeida, Armando
Pacheco, Mário
Pereira, Patrícia
KeywordsNeurosensory toxicity
Antioxidant defenses
Brain ste Antioxidant defenses Brain stereology Wild fish Estuariesreology
Wild fish
Brain stereology
Issue dateSep-2018
JournalMarine Environmental Research
CitationPereira, R., Leite, E., Raimundo, J., Guilherme, S., et. al. (2018). Metals (loids) targeting fish eyes and brain in a contaminated estuary-Uncovering neurosensory (un) susceptibility through bioaccumulation, antioxidant and morphometric profiles. Marine environmental research, 140, 403-411
Abstract(s)This study examined the susceptibility of fish (Liza aurata) eyes and brain to metals(loids) contamination under realistic exposure conditions. A multidimensional approach was applied to fish caught at a chronically contaminated site (BAR) and at a reference site of the Tagus estuary (Portugal), which comprised metals(loids) accumulation in eyes and brain together with a battery of enzymatic and non-enzymatic antioxidants, as well as brain morphometry (i.e. cell density). Trace element levels in the blood, gills, liver and kidney allowed interpretations on their preferential pathway(s) to the eyes and brain. Metals(loids) accumulation pointed out the elevated vulnerability of the fish eyes at BAR, probably related with the direct waterborne uptake. Pb uptake in L. aurata eyes could be associated both with water and indirect pathways. At the most contaminated site, metals(loids) were on the basis of pro-oxidant conditions in the ocular tissues, while no indication of toxicity was recorded in the brain. Overall, the results disclosed a differential bioaccumulation among fish organs, suggesting that, in the L. aurata population studied, metal organotropism underlie the lower susceptibility of the brain comparing to the eyes. However, mechanisms remain little understood and further work is needed.
Publisher version
AccessEmbargoed access (3 Years)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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