Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57877

TitleGeneration of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene
Author(s)Marote, Ana
Pomeshchik, Yuriy
Collin, Anna
Goldwurm, Stefano
Lamas, Nuno J.
Pinto, Luísa
Salgado, A. J.
Roybon, Laurent
KeywordsAged
Animals
Cell Culture Techniques
Cell Line
Female
Humans
Induced Pluripotent Stem Cells
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mice
Mutation
Parkinson Disease
Issue date2018
PublisherElsevier
JournalStem Cell Research
CitationMarote, A., Pomeshchik, Y., Collin, A., Goldwurm, S., et. al.(2018). Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p. G2019S mutation in the LRRK2 gene. Stem cell research, 28, 44-47
Abstract(s)The leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation is the most common genetic cause of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line CSC-41 was generated from a 75-year old patient diagnosed with PD caused by a p.G2019S mutation in LRRK2. Skin fibroblasts were reprogrammed using a non-integrating Sendai virus-based technology to deliver OCT3/4, SOX2, c-MYC and KLF4 transcription factors. The generated iPSC line exhibits expression of common pluripotency markers, differentiates into the three germ layers and has a normal karyotype. The iPSC line can be used to explore the association between LRRK2 mutation and PD.
TypeJournal editorial
URIhttp://hdl.handle.net/1822/57877
DOI10.1016/j.scr.2018.01.022
ISSN1873-5061
e-ISSN1876-7753
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S187350611830028X
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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