Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/57877
Título: | Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene |
Autor(es): | Marote, Ana Pomeshchik, Yuriy Collin, Anna Goldwurm, Stefano Lamas, Nuno J. Pinto, Luísa Salgado, A. J. Roybon, Laurent |
Palavras-chave: | Aged Animals Cell Culture Techniques Cell Line Female Humans Induced Pluripotent Stem Cells Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Mice Mutation Parkinson Disease |
Data: | 2018 |
Editora: | Elsevier 1 |
Revista: | Stem Cell Research |
Citação: | Marote, A., Pomeshchik, Y., Collin, A., Goldwurm, S., et. al.(2018). Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p. G2019S mutation in the LRRK2 gene. Stem cell research, 28, 44-47 |
Resumo(s): | The leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation is the most common genetic cause of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line CSC-41 was generated from a 75-year old patient diagnosed with PD caused by a p.G2019S mutation in LRRK2. Skin fibroblasts were reprogrammed using a non-integrating Sendai virus-based technology to deliver OCT3/4, SOX2, c-MYC and KLF4 transcription factors. The generated iPSC line exhibits expression of common pluripotency markers, differentiates into the three germ layers and has a normal karyotype. The iPSC line can be used to explore the association between LRRK2 mutation and PD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/57877 |
DOI: | 10.1016/j.scr.2018.01.022 |
ISSN: | 1873-5061 |
e-ISSN: | 1876-7753 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S187350611830028X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Marote A CSC41.pdf | 1,85 MB | Adobe PDF | Ver/Abrir |