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TitleGeneration of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene
Author(s)Marote, Ana
Pomeshchik, Yuriy
Collin, Anna
Goldwurm, Stefano
Lamas, Nuno J.
Pinto, Luísa
Salgado, A. J.
Roybon, Laurent
Cell Culture Techniques
Cell Line
Induced Pluripotent Stem Cells
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Parkinson Disease
Issue date2018
JournalStem Cell Research
CitationMarote, A., Pomeshchik, Y., Collin, A., Goldwurm, S., et. al.(2018). Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p. G2019S mutation in the LRRK2 gene. Stem cell research, 28, 44-47
Abstract(s)The leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation is the most common genetic cause of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line CSC-41 was generated from a 75-year old patient diagnosed with PD caused by a p.G2019S mutation in LRRK2. Skin fibroblasts were reprogrammed using a non-integrating Sendai virus-based technology to deliver OCT3/4, SOX2, c-MYC and KLF4 transcription factors. The generated iPSC line exhibits expression of common pluripotency markers, differentiates into the three germ layers and has a normal karyotype. The iPSC line can be used to explore the association between LRRK2 mutation and PD.
TypeJournal editorial
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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