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https://hdl.handle.net/1822/57869
Título: | Genetic variants of vascular endothelial growth factor predict risk and survival of gliomas |
Autor(es): | Linhares, Paulo Pereira, Marta Sofia Carvalho Ribeiro Viana Ferreira, Mónica Amorim, Júlia Nabiço, Rui Pinto, Filipe Costa, Sandra Vaz, Rui Reis, R. M. |
Palavras-chave: | Biomarkers, Tumor Case-Control Studies Genetic Predisposition to Disease Glioma Humans Logistic Models Multivariate Analysis Neovascularization, Pathologic Polymorphism, Single Nucleotide Portugal Prognosis Risk Factors Vascular Endothelial Growth Factor A von Willebrand Factor biomarker prognostic factor risk factor single-nucleotide polymorphisms Vascular endothelial growth factor |
Data: | Mar-2018 |
Editora: | Wolters Kluwer Health |
Revista: | Tumor Biology |
Resumo(s): | The vascular endothelial growth factor regulates angiogenesis that is increased in glioma. VEGF polymorphisms are thought to modulate vascular endothelial growth factor plasma levels and therefore may be implicated in glioma risk. We aimed to clarify the role of VEGF and von Willebrand factor polymorphisms in glioma susceptibility and prognosis. A case-control study of 126 glioma patients and 180 cancer-free controls was performed. Using Sequenom MassARRAY platform, 11 VEGF and 1 VWF polymorphisms were genotyped. Unconditional multivariate logistic regression models were used to calculate odds ratios and 95% confidence intervals. The associations between polymorphisms and survival were evaluated using a Cox regression model. Bonferroni's adjustment was used to correct for multiple testing. The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction. Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma. Our data support a role of VEGF and VWF polymorphisms as glioma biomarkers, with additional potential relevance for molecular stratification of patients for anti-angiogenic therapies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/57869 |
DOI: | 10.1177/1010428318766273 |
ISSN: | 1010-4283 |
e-ISSN: | 1423-0380 |
Versão da editora: | https://journals.sagepub.com/doi/10.1177/1010428318766273 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Linhares P. Genetic variants of vascular endothelial growth factor predict risk and survival of gliomas.pdf | 273,65 kB | Adobe PDF | Ver/Abrir |