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TitleRelationships between neuropsychological and antisaccade measures in multiple sclerosis patients
Author(s)Ferreira, Marisa Borges
Pereira, Paulo Alexandre
Parreira, Marta
Sousa, Ines
Figueiredo, José
Cerqueira, João José
Macedo, Antonio Filipe
KeywordsEye movements
Multiple sclerosis
Stroop test
Inhibitory control
Executive functions
Issue date2018
PublisherPeerj, Inc.
CitationFerreira, M. B., Pereira, P. A., Parreira, M., Sousa, I., Figueiredo, J., Cerqueira, J. J., & Macedo, A. F. (2018). Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients. PeerJ, 6, e5737
Abstract(s)Background: The Stroop test is frequently used to assess deficits in inhibitory control in people with multiple sclerosis (MS). This test has limitations and antisaccade eye movements, that also measure inhibitory control, may be an alternative to Stroop.Objectives: The aim of this study was twofold: (i) to investigate if the performance in the antisaccade task is altered in patients with MS and (ii) to investigate the correlation between performances in neuropsychological tests, the Stroop test and the antisaccade task.Methods: We measured antisaccades (AS) parameters with an infrared eye tracker (SMIRED 250 Hz) using a standard AS paradigm. A total of 38 subjects diagnosed with MS and 38 age and gender matched controls participated in this study. Neuropsychological measures were obtained from the MS group.Results: Patients with MS have higher error rates and prolonged latency than controls in the antisaccade task. There was a consistent association between the Stroop performance and AS latency. Stroop performance but not AS latency was associated with other neuropsychological measures in which the MS group showed deficits.Conclusions: Our findings suggest that AS may be a selective and independent measure to investigate inhibitory control in patients with MS. More studies are necessary to confirm our results and to describe brain correlates associated with impaired performance in the antisaccade task in people diagnosed with MS.
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AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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