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TitleA brain within the heart: A review on the intracardiac nervous system
Author(s)Durães Campos, Isabel
Pinto, Vitor
Sousa, Nuno
Pereira, Vitor H
KeywordsAutonomic nervous system
Intracardiac nervous system
Intracardiac ganglia
Intracardiac neurons
Cardiovascular diseases
Issue dateJun-2018
JournalJournal of Molecular and Cellular Cardiology
Abstract(s)Cardiac function is under the control of the autonomic nervous system, composed by the parasympathetic and sympathetic divisions, which are finely tuned at different hierarchical levels. While a complex regulation occurs in the central nervous system involving the insular cortex, the amygdala and the hypothalamus, a local cardiac regulation also takes place within the heart, driven by an intracardiac nervous system. This complex system consists of a network of ganglionic plexuses and interconnecting ganglions and axons. Each ganglionic plexus contains numerous intracardiac ganglia that operate as local integration centres, modulating the intricate autonomic interactions between the extrinsic and intracardiac nervous systems. Herein, we summarize the current understanding on the intracardiac nervous system, and acknowledge its role in the pathophysiology of cardiovascular diseases.
AccessEmbargoed access (2 Years)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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