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https://hdl.handle.net/1822/5748
Título: | Metaplastic breast carcinomas are basal-like tumours |
Autor(es): | Reis Filho, Jorge S. Milanezi, Fernanda Steele, D. Savage, K. Simpson, Pete T. Nesland, J. M. Pereira, Emílio M. Lakhani, Sunil R. Schmitt, Fernando C. |
Palavras-chave: | Carcinosarcoma Epidermal growth factor receptor (HER1) Myoepithelial Sarcomatoid carcinoma Immunohistochemistry |
Data: | Jul-2006 |
Editora: | Blackwell Publishing |
Revista: | Histopathology |
Citação: | "Histopathology". ISSN 0309-0167. 49:1 (July 2006) 10-21. |
Resumo(s): | Recently, an immunohistochemical panel comprising antibodies against HER2, estrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5 ⁄ 6 was reported to identify basal-like breast carcinomas, as defined by cDNA microarrays. Our aim was to analyse a series of metaplastic breast carcinomas (MBCs) using this panel plus two other basal markers (CK14 and p63) and progesterone receptor (PR), to define how frequently MBCs show a basal-like immunophenotype. Methods and results: Sixty-five cases were retrieved from the pathology archives of the authors’ institutions and reviewed by three of the authors. Immunohistochemistry with antibodies for HER2, ER, EGFR, CK5 ⁄ 6, CK14 and p63 was performed according to standard methods. All but six cases (91%) showed the typical immunoprofile of basal-like tumours (ER– and HER2–, EGFR+ and ⁄ or CK5 ⁄ 6+). When CK14 and p63 were added to the panel, two additional cases could be classified as basal-like. The majority of MBCs lacked PR, except 4 ⁄ 19 (21%) carcinomas with squamous metaplasia. Conclusions: Our results demonstrate that MBCs show a basal-like phenotype, regardless of the type of metaplastic elements. Moreover, as these neoplasms frequently overexpress EGFR (57%), patients with MBC may benefit from treatment with anti-EGFR drugs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/5748 |
DOI: | 10.1111/j.1365-2559.2006.02467.x |
ISSN: | 0309-0167 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Histopathology_Sérgio.pdf | 1,9 MB | Adobe PDF | Ver/Abrir |