In vitro genotoxicity assessment of a dextrin-based hydrogel for biomedical applications

Abstract

[Excerpt] Hydrogels are three dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount of water or biological fluids. Dextrin, a low-molecularweight carbohydrate composed by glucose residues, has been used to develop a novel fully resorbable and injectable hydrogel for biomedical applications. Dextrin was firstly oxidized (ODEX) to introduce aldehyde groups which then reticulate with adipic acid dihydrazide (ADH), forming the dextrin-based hydrogel (HG) [1]. The cross-linked ODEX is an in situ forming hydrogel, which displays a three-dimensional network with inter-connective pores, and is able to incorporate nanogels, cells and biomolecules for biomedical applications [1-3]. [...]