Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/56906
Título: | Gene expression variability across cells and species shapes innate immunity |
Autor(es): | Hagai, Tzachi Chen, Xi Miragaia, Ricardo J. Rostom, Raghd Gomes, Tomás Kunowska, Natalia Henriksson, Johan Park, Jong-Eun Proserpio, Valentina Donati, Giacomo Bossini-Castillo, Lara Vieira Braga, Felipe A. Naamati, Guy Fletcher, James Stephenson, Emily Vegh, Peter Trynka, Gosia Kondova, Ivanela Dennis, Mike Haniffa, Muzlifah Nourmohammad, Armita Lässig, Michael Teichmann,Sarah A. |
Data: | 2018 |
Editora: | Springer Nature |
Revista: | Nature |
Citação: | Hagai, Tzachi; Chen, Xi; Miragaia, Ricardo J.; Rostom, Raghd; Gomes, Tomás; Kunowska, Natalia; Henriksson, Johan; Park, Jong-Eun; Proserpio, Valentina; Donati, Giacomo; Bossini-Castillo, Lara; Vieira Braga, Felipe A.; Naamati, Guy; Fletcher, James; Stephenson, Emily; Vegh, Peter; Trynka, Gosia; Kondova, Ivanela; Dennis, Mike; Haniffa, Muzlifah; Nourmohammad, Armita; Lässig, Michael; Teichmann,Sarah A., Gene expression variability across cells and species shapes innate immunity. Nature, 563, 197-202, 2018 |
Resumo(s): | As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the innate immune response's transcriptional divergence between species and variability in expression among cells. Using bulk and single-cell transcriptomics in fibroblasts and mononuclear phagocytes from different species, challenged with immune stimuli, we map the architecture of the innate immune response. Transcriptionally diverging genes, including those that encode cytokines and chemokines, vary across cells and have distinct promoter structures. Conversely, genes that are involved in the regulation of this response, such as those that encode transcription factors and kinases, are conserved between species and display low cell-to-cell variability in expression. We suggest that this expression pattern, which is observed across species and conditions, has evolved as a mechanism for fine-tuned regulation to achieve an effective but balanced response. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/56906 |
DOI: | 10.1038/s41586-018-0657-2 |
ISSN: | 0028-0836 |
e-ISSN: | 1476-4687 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49035_1.pdf | 4,6 MB | Adobe PDF | Ver/Abrir |