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|Title:||Engineered hydrogel-based matrices for skin wound healing|
|Author(s):||Silva, L. P. da|
Cerqueira, M. T.
Correlo, V. M.
Reis, R. L.
Marques, A. P.
Skin tissue engineering
|Journal:||Woodhead Publishing Series in Biomaterials|
|Citation:||da Silva L. P., Cerqueira M. T., Correlo V. M., Reis R. L., Marques A. P. (2016) Engineered hydrogel-based matrices for skin wound healing, Wound Healing Biomaterials, Vol. 2.|
|Abstract(s):||Hydrogels, due to their hygroscopic nature, have been widely used as wound dressings. Because hydrogels resemble native extracellular matrix (ECM), newer developments aim at recreating three-dimensional ECM-like microenvironments. In general, current hydrogels show limited molecular diffusion and cell binding sites. Spongy-like hydrogels, based on gellan gum polysaccharide, produced by a sequential advanced processing methodology, reunite the benefits of hydrogels along with the capacity to control specific cell behavior. These structures can be stored as dried networks that after re-hydration with a solution containing cells and/or bioactive molecules form the spongy-like hydrogels. Spongy-like hydrogels show improved physical stability, flexibility, viscoelasticity and facilitated manipulation in the incorporation of bioactive molecules and/or cells, in comparison to traditional hydrogels. These characteristics make spongy-like hydrogels attractive for skin regeneration purposes. In this chapter we present the work leading to spongy-like hydrogels, highlighting the possibility of fine-tuning their properties, effects of incorporating hyaluronic acid, stem cells and adult skin cells to meet the demands of specific wound types.Â|
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