Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/54444
Título: | Engineered hydrogel-based matrices for skin wound healing |
Autor(es): | Silva, L. P. da Cerqueira, M. T. Correlo, V. M. Reis, R. L. Marques, A. P. |
Palavras-chave: | Hydrogels Skin tissue engineering Spongy-like hydrogels Wound healing |
Data: | 2016 |
Editora: | Elsevier 1 |
Revista: | Woodhead Publishing Series in Biomaterials |
Citação: | da Silva L. P., Cerqueira M. T., Correlo V. M., Reis R. L., Marques A. P. (2016) Engineered hydrogel-based matrices for skin wound healing, Wound Healing Biomaterials, Vol. 2. |
Resumo(s): | Hydrogels, due to their hygroscopic nature, have been widely used as wound dressings. Because hydrogels resemble native extracellular matrix (ECM), newer developments aim at recreating three-dimensional ECM-like microenvironments. In general, current hydrogels show limited molecular diffusion and cell binding sites. Spongy-like hydrogels, based on gellan gum polysaccharide, produced by a sequential advanced processing methodology, reunite the benefits of hydrogels along with the capacity to control specific cell behavior. These structures can be stored as dried networks that after re-hydration with a solution containing cells and/or bioactive molecules form the spongy-like hydrogels. Spongy-like hydrogels show improved physical stability, flexibility, viscoelasticity and facilitated manipulation in the incorporation of bioactive molecules and/or cells, in comparison to traditional hydrogels. These characteristics make spongy-like hydrogels attractive for skin regeneration purposes. In this chapter we present the work leading to spongy-like hydrogels, highlighting the possibility of fine-tuning their properties, effects of incorporating hyaluronic acid, stem cells and adult skin cells to meet the demands of specific wound types. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/54444 |
ISBN: | 9780081006061 |
DOI: | 10.1016/B978-1-78242-456-7.00011-8 |
ISSN: | 2049-9485 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18724-Book_Chapter_Lsl.pdf | 2,12 MB | Adobe PDF | Ver/Abrir |