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TitlePsoralen analogues : synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
Author(s)Oliveira, Ana M. A. G.
Campos, Ana M. F. Oliveira
Raposo, M. Manuela M.
Machado, António E. H.
Puapairoj, Prapawadee
Pedro, Madalena
Nascimento, Maria São José
Portela, César
Afonso, Carlos A. M.
Pinto, Madalena
Computational studies
Issue dateMar-2006
JournalEuropean Journal of Medical Chemistry
Citation"European Journal of Medical Chemistry". ISSN 0223-5434. 41:3 (2006) 367-372.
Abstract(s)Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.
Publisher version B6VKY-4J3WS1X-1&_coverDate=03%2F31%2F2006&_alid=417621453&_rdoc=1&_fmt=&_orig= search&_qd=1&_cdi=6135&_sort=d&view=c&_acct= C000057396&_version=1&_urlVersion=0&_userid= 2459786&md5=dd4364783c016f3aaf5bd7d04aec2de0
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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