Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/5168

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dc.contributor.authorOliveira, Ana M. A. G.-
dc.contributor.authorCampos, Ana M. F. Oliveira-
dc.contributor.authorRaposo, M. Manuela M.-
dc.contributor.authorMachado, António E. H.-
dc.contributor.authorPuapairoj, Prapawadee-
dc.contributor.authorPedro, Madalena-
dc.contributor.authorNascimento, Maria São José-
dc.contributor.authorPortela, César-
dc.contributor.authorAfonso, Carlos A. M.-
dc.contributor.authorPinto, Madalena-
dc.date.accessioned2006-06-26T15:34:15Z-
dc.date.available2006-06-26T15:34:15Z-
dc.date.issued2006-03-
dc.identifier.citation"European Journal of Medical Chemistry". ISSN 0223-5434. 41:3 (2006) 367-372.eng
dc.identifier.issn0223-5434eng
dc.identifier.urihttp://hdl.handle.net/1822/5168-
dc.description.abstractEight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.eng
dc.description.sponsorshipFAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais - Brasil).por
dc.description.sponsorshipCNPq (Conselho Nacional do Desenvolvimento Científico e Tecnológico - Brasil).por
dc.description.sponsorshipFEDER.por
dc.description.sponsorshipFundação para a Ciência e Tecnologia - I&D nº 226/9; CQ-UM; PRAXIS XXI/BD/19707/99); SFRH/BD/1456/2000; SFRH/BD/3036/2000.por
dc.description.sponsorshipPOCTI.por
dc.language.isoengeng
dc.publisherElseviereng
dc.rightsopenAccesseng
dc.subjectFurocoumarinseng
dc.subjectBenzopsoralenseng
dc.subjectAntitumoreng
dc.subjectComputational studieseng
dc.titlePsoralen analogues : synthesis, inhibitory activity of growth of human tumor cell lines and computational studieseng
dc.typearticlepor
dc.peerreviewedyeseng
dc.relation.publisherversionhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi= B6VKY-4J3WS1X-1&_coverDate=03%2F31%2F2006&_alid=417621453&_rdoc=1&_fmt=&_orig= search&_qd=1&_cdi=6135&_sort=d&view=c&_acct= C000057396&_version=1&_urlVersion=0&_userid= 2459786&md5=dd4364783c016f3aaf5bd7d04aec2de0eng
sdum.number3eng
sdum.pagination367-372eng
sdum.publicationstatuspublishedeng
sdum.volume41eng
oaire.citationStartPage367por
oaire.citationEndPage372por
oaire.citationIssue3por
oaire.citationVolume41por
dc.identifier.doi10.1016/j.ejmech.2005.10.016por
dc.identifier.pmid16439037por
dc.subject.wosScience & Technologypor
sdum.journalEuropean Journal of Medical Chemistrypor
Appears in Collections:CDQuim - Artigos (Papers)

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