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TitleAtypical, non-standard functions of the microtubule associated Tau protein
Author(s)Sotiropoulos, I.
Galas, Marie-Christine
Silva, Joana Margarida Gonçalves Mota
Skoulakis, Efthimios
Wegmann, Susanne
Maina, Mahmoud Bukar
Blum, David
Sayas, Carmen Laura
Mandelkow, Eva-Maria
Sousa, Nuno
et. al.
Alzheimer’s disease
Neuronal function
Subcellular localization
Tau isoform
Issue date11-Nov-2017
PublisherBioMed Central
JournalActa Neuropathologica Communications
CitationSotiropoulos, I., Galas, M. C., Silva, J. M., et. al.(2017). Atypical, non-standard functions of the microtubule associated Tau protein. Acta neuropathologica communications, 5(1), 91
Abstract(s)Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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