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TitleCognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
Author(s)Cabral, Joana
Vidaurre, Diego
Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Moreira, Pedro Miguel Silva
Soares, José Miguel Montenegro
Deco, Gustavo
Sousa, Nuno
Kringelbach, Morten L.
Issue date11-Jul-2017
PublisherNature Publishing Group
JournalScientific Reports
CitationCabral, J., Vidaurre, D., Marques, P., Magalhães, R., Moreira, P. S., et. al. (2017). Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest. Scientific Reports, 7(1)
Abstract(s)Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns - or states - are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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