Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49348
Título: | Analyzing and designing cell factories with OptFlux |
Autor(es): | Vilaça, Paulo Ricardo Carvalho Maia, Paulo Giesteira, Hugo Miguel Melo Rocha, Isabel Rocha, Miguel |
Palavras-chave: | Computational biology and bioinformatics Systems biology Metabolic engineering Flux-balance analysis |
Data: | 2018 |
Editora: | Springer |
Revista: | Methods in Molecular Biology |
Citação: | Vilaça, P.; Maia, Paulo; Giesteira, Hugo; Rocha, Isabel; Rocha, Miguel, Analyzing and designing cell factories with Optflux. In Marco Fondi, Metabolic Network Reconstruction and Modeling: Methods and Protocols, Vol. Methods in Molecular Biology 1716, Springer, 2018. ISBN: 978-1-4939-7528-0, 37-76 |
Resumo(s): | OptFlux was launched in 2010 as the first open-source and user-friendly platform containing all the major methods for performing metabolic engineering tasks in silico. Main features included the possibility of performing microbial strain simulations with widely used methods such as Flux Balance Analysis and strain design using Evolutionary Algorithms. Since then, OptFlux suffered a major re-factoring to improve its efficiency and reliability, while many features were added in the form of novel plug-ins, such as the BioVisualizer and the over/under expression plug-ins. The current chapter described the main mathematical formulations of the major methods implemented within OptFlux, also providing a detailed guide on the usage of those functionalities. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/49348 |
ISBN: | 978-1-4939-7528-0 |
DOI: | 10.1007/978-1-4939-7528-0_2 |
ISSN: | 1064-3745 |
Versão da editora: | http://www.springer.com/us/book/9781493975273#aboutAuthors |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
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document_47340_1.pdf Acesso restrito! | 1,75 MB | Adobe PDF | Ver/Abrir |