Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49053
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Moukambi, Félicien | por |
dc.contributor.author | Rodrigues, Vasco | por |
dc.contributor.author | Fortier, Yasmina | por |
dc.contributor.author | Rabezanahary, Henintsoa | por |
dc.contributor.author | Borde, Chloé | por |
dc.contributor.author | Krust, Bernard | por |
dc.contributor.author | Andreani, Guadalupe | por |
dc.contributor.author | Silvestre, Ricardo Jorge Leal | por |
dc.contributor.author | Petrovas, Constantinos | por |
dc.contributor.author | Laforge, Mireille | por |
dc.contributor.author | Estaquier, Jérôme | por |
dc.date.accessioned | 2018-01-05T17:36:06Z | - |
dc.date.available | 2018-01-05T17:36:06Z | - |
dc.date.issued | 2017-02-20 | - |
dc.identifier.citation | Moukambi, F., Rodrigues, V., Fortier, Y., Rabezanahary, H., Borde, C., Krust, B., et. al. (2017). CD4 T follicular helper cells and HIV infection: friends or enemies?. Frontiers in immunology, 8. | por |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://hdl.handle.net/1822/49053 | - |
dc.description.abstract | Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection. | por |
dc.description.sponsorship | JE from the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) and from The Canadian HIV Cure Enterprise Team Grant HIG-13305 from the Canadian Institutes of Health Research (CIHR) in partnership with CANFAR and IAS. FM is supported by a fellowship from Fondation du CHU de Québec. CB and YF are supported by fellowships from ANRS. JE acknowledges the support of the Canada Research Chair program. RS is supported by FCT—Fundaçao para a Ciência e a Tecnologia/MEC—Ministério da Educaçao e Ciência através de fundos nacionais e quando aplicavel cofinanciado pelo FEDER, no âmbito do Acordo de Parceria PT2020 referente à unidade de investigaçao n°4293. RS is supported by the Fundaçao para a Ciência e a Tecnologia (FCT) (IF/00021/2014) | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.rights | openAccess | por |
dc.subject | AIDS | por |
dc.subject | Tfh | por |
dc.subject | CD4 | por |
dc.subject | B cell | por |
dc.subject | Vaccine | por |
dc.subject | Pathogen | por |
dc.subject | SIV | por |
dc.subject | Reservoir | por |
dc.title | CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fimmu.2017.00135/full | por |
oaire.citationIssue | 135 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2017-12-19T15:11:53Z | - |
dc.identifier.doi | 10.3389/fimmu.2017.00135 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in Immunology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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fimmu-08-00135.pdf | 1,34 MB | Adobe PDF | Ver/Abrir |