Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49011
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Dias, Emanuel Carvalho | por |
dc.contributor.author | Miranda, Alice | por |
dc.contributor.author | Martinho, Olga | por |
dc.contributor.author | Mota, Paulo | por |
dc.contributor.author | Costa, Ângela Margarida Amorim | por |
dc.contributor.author | Nogueira-Silva, Cristina | por |
dc.contributor.author | Moura, Rute S. | por |
dc.contributor.author | Alenina, Natalia | por |
dc.contributor.author | Bader, Michael | por |
dc.contributor.author | Autorino, Riccardo | por |
dc.contributor.author | Lima, Estêvão Augusto Rodrigues de | por |
dc.contributor.author | Correia-Pinto, Jorge | por |
dc.date.accessioned | 2018-01-04T12:08:11Z | - |
dc.date.available | 2018-01-04T12:08:11Z | - |
dc.date.issued | 2017-11-03 | - |
dc.identifier.citation | Carvalho-Dias, E., Miranda, A., Martinho, O., Mota, P., Costa, Â., Nogueira-Silva, C., ... & Lima, E. (2017). Serotonin regulates prostate growth through androgen receptor modulation. Scientific reports, 7(1), 15428 | por |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/1822/49011 | - |
dc.description | Serotonin regulates prostate growth through androgen receptor modulation | por |
dc.description.abstract | Aging and testosterone almost inexorably cause benign prostatic hyperplasia (BPH) in Human males. However, etiology of BPH is largely unknown. Serotonin (5-HT) is produced by neuroendocrine prostatic cells and presents in high concentration in normal prostatic transition zone, but its function in prostate physiology is unknown. Previous evidence demonstrated that neuroendocrine cells and 5-HT are decreased in BPH compared to normal prostate. Here, we show that 5-HT is a strong negative regulator of prostate growth. In vitro, 5-HT inhibits rat prostate branching through down-regulation of androgen receptor (AR). This 5-HT's inhibitory mechanism is also present in human cells of normal prostate and BPH, namely in cell lines expressing AR when treated with testosterone. In both models, 5-HT's inhibitory mechanism was replicated by specific agonists of 5-Htr1a and 5-Htr1b. Since peripheral 5-HT production is specifically regulated by tryptophan hydroxylase 1(Tph1), we showed that Tph1 knockout mice present higher prostate mass and up-regulation of AR when compared to wild-type, whereas 5-HT treatment restored the prostate weight and AR levels. As 5-HT is decreased in BPH, we present here evidence that links 5-HT depletion to BPH etiology through modulation of AR. Serotoninergic prostate pathway should be explored as a new therapeutic target for BPH. | por |
dc.description.sponsorship | Projects NORTE-01-0246-FEDER-000012, NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Program (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and Bolsa de Investigação GSK Inovação em Urologia 2012 | por |
dc.language.iso | eng | por |
dc.publisher | Nature Publishing Group | por |
dc.rights | openAccess | por |
dc.title | Serotonin regulates prostate growth through androgen receptor modulation | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-017-15832-5 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2017-12-19T09:55:53Z | - |
dc.identifier.doi | 10.1038/s41598-017-15832-5 | por |
dc.identifier.pmid | 29133842 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Scientific Reports | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |