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dc.contributor.authorCosta, Allini Mafra dapor
dc.contributor.authorFregnani, José Humberto Tavares Guerreiropor
dc.contributor.authorPastrez, Paula Roberta Aguiarpor
dc.contributor.authorMariano, Vânia Sammartinopor
dc.contributor.authorSilva, Estela Mariapor
dc.contributor.authorScapulatempo-Neto, Cristovampor
dc.contributor.authorGuimarães, Denise Peixotopor
dc.contributor.authorVilla, Luisa Linapor
dc.contributor.authorSichero, Laurapor
dc.contributor.authorSyrjanen, Karipor
dc.contributor.authorLongatto Filho, Adhemarpor
dc.description.abstractBackground: Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that may have impact on survival of ESCC. Methods: We conducted a prospective cohort study. By using multiplex PCR, we determined the prevalence of high risk HPV in ESCC, and evaluated the immunohistochemical expression of p16 and p53, molecular markers related to esophageal carcinogenesis in order to verify the potential influence of these variables in patients's survival. Survival rates were estimated using Kaplan-Meier methods. A multivariate confirmatory model was performed using Cox proportional hazards regression. Results: Twelve (13.8%) of 87 patients were HPV-DNA positive. Positive reactions of p16 and p53 were 10.7% and 68.6%, respectively. Kaplan-Meier analysis indicated that men (p = 0.025) had poor specific-cancer survival and a shorter progression-free survival (p = 0.050) as compared to women; III or IV clinical stage (p < 0.019) had poor specific-cancer survival and a shorter progression-free survival (p < 0.001) compared to I and II clinical stage; not submitted to surgery (< 0.001) and not submitted to chemoradiotherapy (p = 0.039) had a poor specific-cancer survival, as well. The multivariate analysis showed that HPV, p16 and p53 status are not predictive parameters of progression-free and specific-cancer survival. Conclusion: HPV infection and p53 and p16 expression are not prognostic factors in ESCC.por
dc.description.sponsorshipCNPq Universal for providing supplies to the largest study, of which this study is a part of, entitled “The role of human papillomavirus (HPV) as the etiologic agent of esophageal cancer. A cross-sectional study, case-control and longitudinal at Barretos Cancer Hospital”; (Grant number 482666/2012–9 to ALF); INCT HPV [Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [Grant number 08/57889–1 to LLV]; Conselho Nacional de Desenvolvimento Científico e Tencnológico (CNPq) (Grant number 573799/ 2008–3 to LLV)].por
dc.publisherBioMed Central (BMC)por
dc.relation573799/ 2008–3por
dc.subjectHuman Papillomaviruspor
dc.subjectEsophageal cancerpor
dc.titleHPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?por
dc.subject.wosScience & Technologypor
sdum.journalInfectious Agents and Cancerpor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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