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https://hdl.handle.net/1822/48204
Título: | Molecular dynamics simulations together with experimental studies reveal strong membrane activity of a small peptide |
Autor(es): | Antunes, José Egipto Ferreira Azóia, Nuno G. Cavaco-Paulo, Artur |
Data: | 13-Mar-2016 |
Editora: | American Chemical Society |
Revista: | Abstracts of Papers of the American Chemical Society |
Citação: | Antunes, Egipto; Azoia, Nuno G.; Cavaco-Paulo, Artur, Molecular dynamics simulations together with experimental studies reveal strong membrane activity of a small peptide. 251st American Chemical Society National Meeting & Exposition - Computers in Chemistry. No. 629, San Diego, USA, March 13-17, 2016. |
Resumo(s): | Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) are generally defined as small cationic peptides with the ability to interact with lipidic membranes, in a process driven by electrostatic and hydrophobic processes. The interaction with CPPs is known to lead to its translocation across the membrane, while with AMPs lead to membrane damage. Here we present one synthetic anionic peptide, which strongly interacts with model membranes, showing properties of the two peptide classes, namely the translocation through lipidic membranes on a mechanism usually described for cationic CPPs and membrane destabilization like AMPs promote. These properties were shown through molecular dynamic studies, experimental studies with liposomes and mammalian cells in vitro. Based on the peptide properties here demonstrated, small modifications in its structure could make it a very promising tool for drug delivery. |
Tipo: | Resumo em ata de conferência |
Descrição: | 251st American Chemical Society National Meeting & Exposition - Computers in Chemistry |
URI: | https://hdl.handle.net/1822/48204 |
ISSN: | 0065-7727 |
Versão da editora: | https://www.acs.org/content/acs/en/meetings/spring-2016.html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46746_1.pdf | 642,37 kB | Adobe PDF | Ver/Abrir |