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TitlePortrait of gene expression in C. glabrata with stress induced by drugs
Author(s)Rodrigues, Célia Fortuna
Rodrigues, Maria Elisa Costa
Henriques, Mariana
KeywordsCandida glabrata
Issue date22-Sep-2017
CitationRodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Portrait of gene expression in C. glabrata with stress induced by drugs. Eurobiofilms 2017 - 5th European Congress on Microbial Biofilms. No. 134, Amesteram, Netherlands, 19-22 September, 204, 2017.
Abstract(s)Candidiasis have globally increased over the last years, being a major cause of morbidity and mortality, especially in immunosuppressed and hospitalized patients. Candida albicans remains to be the most common species responsible in candidiasis, but Candida glabrata has appeared as second most common Candida in the USA and the third in Europe. Biofilms of this species are extremely difficult to eradicate and are a source of many recalcitrant infections. The goal of this study was to evaluate how C. glabrata cells try to adjust their biofilm composition in response to an antifungal drug treatment based on a series of profiles of eight genes expression - BGL2, FKS1, FKS2, GAS2, KHN1, UPG1, XOG1 and MNN2 known to be related to the production of -1,3, -1,6-glucans and mannans.
DescriptionEurobiofilms 2017 - 5th European Congress on Microbial Biofilms
Publisher version
AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

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