Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46258
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Lopes, Sofia Oliveira | por |
dc.contributor.author | Teplytska, Larysa | por |
dc.contributor.author | Silva, João Luís Vaz Lima da | por |
dc.contributor.author | Dioli, Chrysoula | por |
dc.contributor.author | Trindade, Rita | por |
dc.contributor.author | Morais, Mónica | por |
dc.contributor.author | Webhofer, Christian | por |
dc.contributor.author | Maccarrone, Guiseppina | por |
dc.contributor.author | Almeida, Osborne | por |
dc.contributor.author | Turck, Christoph | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Sotiropoulos, I. | por |
dc.contributor.author | Filiou, Michaela | por |
dc.date.accessioned | 2017-07-25T08:52:38Z | - |
dc.date.available | 2017-07-25T08:52:38Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1047-3211 | por |
dc.identifier.uri | https://hdl.handle.net/1822/46258 | - |
dc.description.abstract | Tau protein in dendrites and synapses has been recently implicated in synaptic degeneration and neuronal malfunction. Chronic stress, awell-known inducer of neuronal/synaptic atrophy, triggers hyperphosphorylation of Tau protein and cognitive deficits. However, the cause–effect relationship between these events remains to be established. To test the involvement of Tau in stress-induced impairments of cognition,we investigated the impact of stress on cognitive behavior, neuronal structure, and the synaptic proteome in the prefrontal cortex (PFC) of Tau knock-out (Tau-KO) and wild-type (WT) mice. Whereas exposure to chronic stress resulted in atrophy of apical dendrites and spine loss in PFC neurons as well as significant impairments in working memory in WT mice, such changes were absent in Tau-KO animals. Quantitative proteomic analysis of PFC synaptosomal fractions, combined with transmission electron microscopy analysis, suggested a prominent role for mitochondria in the regulation of the effects of stress. Specifically, chronically stressed animals exhibit Tau-dependent alterations in the levels of proteins involved in mitochondrial transport and oxidative phosphorylation aswell as in the synaptic localization of mitochondria in PFC. These findings provide evidence for a causal role of Tau in mediating stress-elicited neuronal atrophy and cognitive impairment and indicate that Tau may exert its effects through synaptic mitochondria. | por |
dc.description.sponsorship | This work was funded by the Portuguese Foundation for Science & Technology (FCT, grant number NMC-113934 to I.S.), the EU Consortium Switchbox (grant number Health-FP7-2010-259772 to O.F.X.A. and N.S.), the Deutsche Forschungsgemeinschaft (grant number FI 1895/1-1 to M.D.F.) and the Max Planck Society (M.D.F., G.M., C.W.T., and O.F.X.A.). In addition, this workwas also co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER) (N.S.). S.L. and I.S. are holders of FCT Fellowships. J.V-S. is a recipient of a PhD fellowship (PD/ BD/105938/2014) of the University of Minho MD/PhD Program funded by FCT. | por |
dc.language.iso | eng | por |
dc.publisher | Oxford University Press | por |
dc.relation | info:eu-repo/grantAgreement/FCT/PD/PD%2FBD%2F105938%2F2014/PT | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/259772/EU | - |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113934/PT | - |
dc.rights | openAccess | por |
dc.subject | Chronic stress | por |
dc.subject | Dendritic atrophy | por |
dc.subject | Mitochondria | por |
dc.subject | Prefrontal cortex | por |
dc.subject | Tau knock-out | por |
dc.title | Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: role of synaptic mitochondria | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://cercor.oxfordjournals.org/ | por |
oaire.citationStartPage | 2580 | por |
oaire.citationEndPage | 2591 | por |
oaire.citationIssue | 4 | por |
oaire.citationTitle | Cerebral Cortex | por |
oaire.citationVolume | 27 | por |
dc.date.updated | 2017-07-20T14:18:03Z | - |
dc.identifier.doi | 10.1093/cercor/bhw057 | por |
dc.identifier.pmid | 27073221 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cerebral Cortex | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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lopes_et_al-cercortex-2016.pdf | 552,97 kB | Adobe PDF | Ver/Abrir |