Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46255
Título: | Getting a handle on embryo limb development: molecular interactions driving limb outgrowth and patterning |
Autor(es): | Sheeba, Caroline Jeya Andrade, Raquel P. Esteves, Isabel Maria Mestre Marques Palmeirim Alfarra |
Palavras-chave: | Limb development Patterning Limb molecular clock Molecular interactions Signaling gradients |
Data: | 2016 |
Editora: | Elsevier 1 |
Revista: | Seminars in Cell and Developmental Biology |
Resumo(s): | Development of the vertebrate embryo involves multiple segmentation processes to generate a functional, articulated organism. Cell proliferation, differentiation and patterning involve spatially and temporally regulated gene expression and signal transduction mechanisms. The developing vertebrate limb is an excellent model to study such fine-tuned regulations, whereby cells proliferate and are differentially sculptured along the proximal-distal, anterior-posterior and dorsal-ventral axes to form a functional limb. Complementary experimental approaches in different organisms have enhanced our knowledge on the molecular events underlying limb development. Herein, we summarize the current knowledge of the main signaling mechanisms governing vertebrate limb initiation, outgrowth, specification of limb segments and termination. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/46255 |
DOI: | 10.1016/j.semcdb.2015.01.007 |
ISSN: | 1084-9521 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S1084952115000099 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-s1084952115000099-main.pdf | 2,16 MB | Adobe PDF | Ver/Abrir |