Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44853
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Mesquita, Sandro Gabriel Ferreira Dá | por |
dc.contributor.author | Ferreira, Ana Catarina | por |
dc.contributor.author | Sousa, João Carlos | por |
dc.contributor.author | Neves, Margarida Correia | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Marques, Fernanda | por |
dc.date.accessioned | 2017-02-27T17:08:51Z | - |
dc.date.available | 2017-02-27T17:08:51Z | - |
dc.date.issued | 2016-09 | - |
dc.date.submitted | 2016-01 | - |
dc.identifier.citation | Dá Mesquita, S., Ferreira, A. C., Sousa, J. C., Correia-Neves, M., Sousa, N., & Marques, F. (2016). Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neuroscience & Biobehavioral Reviews, 68, 547-562. doi: 10.1016/j.neubiorev.2016.06.014 | por |
dc.identifier.issn | 0149-7634 | por |
dc.identifier.uri | https://hdl.handle.net/1822/44853 | - |
dc.description.abstract | Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is growing along with the increased life expectancy. Although the accumulation and deposition of amyloid beta (Aß) peptides in the brain is viewed as one of the pathological hallmarks of AD and underlies, at least in part, brain cell dysfunction and behavior alterations, the etiology of this neurodegenerative disease is still poorly understood. Noticeably, increased amyloid load is accompanied by marked inflammatory alterations, both at the level of the brain parenchyma and at the barriers of the brain. However, it is debatable whether the neuroinflammation observed in aging and in AD, together with alterations in the peripheral immune system, are responsible for increased amyloidogenesis, decreased clearance of Aß out of the brain and/or the marked deficits in memory and cognition manifested by AD patients. Herein, we scrutinize some important traits of the pathophysiology of aging and AD, focusing on the interplay between the amyloidogenic pathway, neuroinflammation and the peripheral immune system. | por |
dc.description.sponsorship | Fundação Calouste Gulbenkian (Programa Gulbenkian Inovar em Saúde), with the reference UMINHO/BI/155/2015. (FCT, Portugal)/FEDER and Programa Operacional Potencial Humano (POPH/FSE); This work was supported by FCT and COMPETE through the project EXPL/NEU-OSD/2196/2013 and the Bial Foundation through the Grant 217/12 | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F51989%2F2012/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/135221/PT | por |
dc.rights | openAccess | por |
dc.subject | Alzheimer's disease | por |
dc.subject | Aging | por |
dc.subject | Amyloid beta | por |
dc.subject | Cognition | por |
dc.subject | Blood-brain barrier | por |
dc.subject | Choroid plexus | por |
dc.subject | Cerebrospinal fluid | por |
dc.subject | Glial cells | por |
dc.subject | Neurons | por |
dc.subject | Cytokines | por |
dc.subject | Neuroinflammation | por |
dc.subject | Immune system | por |
dc.title | Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0149763416300094 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 547 | por |
oaire.citationEndPage | 562 | por |
oaire.citationTitle | Neuroscience and Biobehavioral Reviews | por |
oaire.citationVolume | 68 | por |
dc.date.updated | 2017-02-13T13:01:00Z | - |
dc.identifier.doi | 10.1016/j.neubiorev.2016.06.014 | por |
dc.identifier.pmid | 27328788 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Neuroscience and Biobehavioral Reviews | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-s0149763416300094-main.pdf | 1,38 MB | Adobe PDF | Ver/Abrir |