Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/41018
Título: | Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis |
Autor(es): | Castro, Joana Vieira de Gonçalves, Céline S. Costa, Sandra Linhares, Paulo Vaz, Rui Nabiço, Ricardo Amorim, Júlia Pereira, Marta Viana Reis, R. M. Costa, Bruno M |
Palavras-chave: | Glioma Glioblastoma Transforming growth factor beta 1 Single nucleotide polymorphisms Risk Prognosis |
Data: | 2015 |
Editora: | Springer |
Revista: | Tumor Biology |
Resumo(s): | Transforming growth factor beta (TGF-ß) plays an important role in carcinogenesis. Two polymorphisms in the TGF-ß1 gene (-509C/T and 869T/C) were described to influence susceptibility to gastric and breast cancers. The 869T/C polymorphism was also associated with overall survival in breast cancer patients. In the present study, we investigated the relevance of these TGF-ß1 polymorphism in glioma risk and prognosis. A case-control study that included 114 glioma patients and 138 cancer-free controls was performed. Single nucleotide polymorphisms (SNPs) were evaluated by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). Univariate and multivariate logistic regression analyses were used to calculate odds ratio (OR) and 95 % confidence intervals (95 % CI). The influence of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma patient survival was evaluated by a Cox regression model adjusted for patients' age and sex and represented in Kaplan-Meier curves. Our results demonstrated that TGF-ß1 gene polymorphisms -509C/T and 869T/C are not significantly associated with glioma risk. Survival analyses showed that the homozygous -509TT genotype associates with longer overall survival of glioblastoma (GBM) patients when compared with patients carrying CC + CT genotypes (OR, 2.41; 95 % CI, 1.06-5.50; p = 0.036). In addition, the homozygous 869CC genotype is associated with increased overall survival of GBM patients when compared with 869TT + TC genotypes (OR, 2.62; 95 % CI, 1.11-6.17; p = 0.027). In conclusion, this study suggests that TGF-ß1 -509C/T and 869T/C polymorphisms are not significantly associated with risk for developing gliomas but may be relevant prognostic biomarkers in GBM patients. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/41018 |
DOI: | 10.1007/s13277-015-3343-0 |
ISSN: | 1010-4283 |
Versão da editora: | http://www.springer.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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tgfbeta1 snps in glioma - vieira de castro_2015 - tumor biology_merged.pdf | postprint autor | 1,16 MB | Adobe PDF | Ver/Abrir |