Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/39807

TitleNew self-assembled supramolecular hydrogels based on dehydropeptides
Author(s)Vilaça, Maria Helena Pereira
Pereira, G.
Castro, T. G.
Hermenegildo, Bruno Filipe Costa
Shi, J.
Faria, T. Q.
Micaelo, N. M.
Brito, Rui Miguel Magalhães
Xu, B.
Castanheira, Elisabete M. S.
Martins, J. A.
Ferreira, Paula M. T.
KeywordsHydrogel
Self-assembly
Fluorescence
Dehydropeptides
Issue date2-Jul-2015
PublisherRoyal Society of Chemistry
JournalJournal of Materials Chemistry B
CitationVilaca, H., Pereira, G., Castro, T. G., Hermenegildo, B. F., Shi, J., Faria, T. Q., . . . Ferreira, P. M. T. (2015). New self-assembled supramolecular hydrogels based on dehydropeptides. Journal of Materials Chemistry B, 3(30), 6355-6367. doi: 10.1039/c5tb00501a
Abstract(s)Supramolecular hydrogels rely on small molecules that self-assemble in water as a result of the cooperative effect of several relatively weak intermolecular interactions. Peptide-based low molecular weight hydrogelators have attracted enormous interest owing to the simplicity of small molecules combined with the versatility and biocompatibility of peptides. In this work, naproxen, a well known non-steroidal anti-inflammatory drug, was N-conjugated with various dehydrodipeptides to give aromatic peptide amphiphiles that resist proteolysis. Molecular dynamics simulations were used to obtain insight into the underlying molecular mechanism of self-assembly and to rationalize the design of this type of hydrogelators. The results obtained were in excellent agreement with the experimental observations. Only dehydrodipeptides having at least one aromatic amino acid gave hydrogels. The characterization of the hydrogels was carried out using transmission electron microscopy (TEM), circular dichroism (CD), fluorescence spectroscopy and also rheological assays.
TypeArticle
URIhttp://hdl.handle.net/1822/39807
DOI10.1039/c5tb00501a
ISSN2050-7518
Publisher versionhttp://pubs.rsc.org/en/content/articlepdf/2015/tb/c5tb00501a
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)
CDQuim - Artigos (Papers)

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