Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/39145
Título: | A new and efficient synthesis of N3-cycloalkylamino-6,8-diaminopurines |
Autor(es): | Fernandes, Soraia P. Proença, M. Fernanda R. P. Dias, Alice |
Palavras-chave: | Química Orgânica |
Data: | 1-Dez-2015 |
Resumo(s): | [Excerpt] The purine core is a privileged scaffold in medicinal chemistry and the biological relevance of purine derivatives makes them attractive targets in the preparation of combinatorial libraries.1,2 In particular, there is a great interest in the synthesis of 8-substituted purines due to their important potential as antiviral and anticancer agents.3 Reports on 8-aminopurines are limited and general methods to obtain these purine derivatives are still needed.4 Cyclic amines and hydrazines are key structural motifs in various bioactive agents.5 Here we report a novel, efficient and inexpensive method for the synthesis of 6,8-diaminopurines 4 incorporating cycloalkylamino substituents at N3position of the purine ring. (...) |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/39145 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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QOT_A new and efficient synthesis of N3-cycloalkylamino-6,8-diaminopurines.pdf Acesso restrito! | 586,79 kB | Adobe PDF | Ver/Abrir |