Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/39145
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Fernandes, Soraia P. | por |
dc.contributor.author | Proença, M. Fernanda R. P. | por |
dc.contributor.author | Dias, Alice | por |
dc.date.accessioned | 2015-12-23T00:22:46Z | - |
dc.date.issued | 2015-12-01 | - |
dc.identifier.uri | https://hdl.handle.net/1822/39145 | - |
dc.description.abstract | [Excerpt] The purine core is a privileged scaffold in medicinal chemistry and the biological relevance of purine derivatives makes them attractive targets in the preparation of combinatorial libraries.1,2 In particular, there is a great interest in the synthesis of 8-substituted purines due to their important potential as antiviral and anticancer agents.3 Reports on 8-aminopurines are limited and general methods to obtain these purine derivatives are still needed.4 Cyclic amines and hydrazines are key structural motifs in various bioactive agents.5 Here we report a novel, efficient and inexpensive method for the synthesis of 6,8-diaminopurines 4 incorporating cycloalkylamino substituents at N3position of the purine ring. (...) | por |
dc.description.sponsorship | FCT (NMR portuguese network); FCT and FEDER-COMPETE-QREN-EU [Pest-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)] | por |
dc.language.iso | eng | por |
dc.rights | restrictedAccess | por |
dc.subject | Química Orgânica | por |
dc.title | A new and efficient synthesis of N3-cycloalkylamino-6,8-diaminopurines | por |
dc.type | conferenceAbstract | - |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationConferenceDate | 1 – 3 Dez. 2015 | por |
sdum.event.type | congress | por |
oaire.citationConferencePlace | Porto, Portugal | por |
oaire.citationTitle | Congresso de Química Orgânica e Terapêutica | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
sdum.conferencePublication | Congresso de Química Orgânica e Terapêutica | por |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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QOT_A new and efficient synthesis of N3-cycloalkylamino-6,8-diaminopurines.pdf Acesso restrito! | 586,79 kB | Adobe PDF | Ver/Abrir |