Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/39114
Título: | The synthesis of novel 5-aminoimidazoles derivatives with anticancer activity |
Autor(es): | Fernandes, Soraia P. Proença, M. Fernanda R. P. Wilson, Cristina Pereira Dias, Alice |
Palavras-chave: | Química Orgânica Biologia |
Data: | 8-Mai-2015 |
Resumo(s): | [Excerpt] The imidazole nucleus is present in a significant number of biomolecules and the inclusion of this moiety in organic scaffolds is considered an important synthetic strategy in drug discovery.[1] 5-Aminoimidazoles are interesting building blocks in medicinal chemistry since they are key components in many bioactive molecules and their derivatives showed a wide pharmacological potential as anticancer drugs.[1] The hydrazones constitute an important class of biological active drug molecules due to their wide range of pharmacological properties that include antitumoral activities.[2] Amidrazone derivatives could be considered very promising in the perspective of new drug discovery, because they are very effective as building blocks to obtain various heterocycles.[2,3] The α-hydrazononitriles are a special case of compounds belonging to the family of hydrazones that is less common in the literature, but has a great interest due to their pharmacological applications.[4] (...) |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/39114 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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SQM_The Synthesis of Novel 5-Aminoimidazoles derivatives with potential anticancer activity - Soraia Fernandes.pdf Acesso restrito! | 91,81 kB | Adobe PDF | Ver/Abrir |