Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/33602
Título: | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
Autor(es): | Reis, R. M. Campa, Danielr Martino, Alessandro Sainz, Juan Buda, Gabriele Jamroziak, Krzysztof Weinhold, Niels García-Sanz, Ramón Jurado, Manuel Ríos, Rafael Szemraj-Rogucka, Zofia Marques, Herlander Lesueur, Fabienne Bugert, Peter Moreno, Victor Szemraj, Janusz Orciuolo, Enrico Gemignani, Federica Petrini, Mario Goldschmidt, Hartmut Landi, Stefano Canzian, Federico |
Palavras-chave: | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
Data: | Mai-2012 |
Editora: | Blackwell Publishing |
Revista: | British Journal of Haematology |
Resumo(s): | Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/33602 |
DOI: | 10.1111/j.1365-2141.2012.09047.x |
ISSN: | 0007-1048 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2012.09047.x/pdf |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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campa d_british j haemat 2012.pdf Acesso restrito! | 88,51 kB | Adobe PDF | Ver/Abrir |