Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/32920
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Cruz, Andrea Patrícia Ribeiro | por |
dc.contributor.author | Torrado, Egídio | por |
dc.contributor.author | Carmona, Jenny | por |
dc.contributor.author | Fraga, Alexandra G. | por |
dc.contributor.author | Costa, Patrício Soares | por |
dc.contributor.author | Rodrigues, Fernando | por |
dc.contributor.author | Appelberg, Rui | por |
dc.contributor.author | Neves, Margarida Correia | por |
dc.contributor.author | Cooper, Andrea M. | por |
dc.contributor.author | Saraiva, Margarida | por |
dc.contributor.author | Pedrosa, Jorge | por |
dc.contributor.author | Castro, António G. | por |
dc.date.accessioned | 2015-01-15T18:50:23Z | - |
dc.date.available | 2015-01-15T18:50:23Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0264-410X | por |
dc.identifier.uri | https://hdl.handle.net/1822/32920 | - |
dc.description.abstract | Mycobacterium bovis Bacille Calmette-Guerin (BCG) is the only vaccine in use to prevent Mycobacterium tuberculosis (Mtb) infection. Here we analyzed the protective efficacy of BCG against Mtb challenges 21 or 120 days after vaccination. Only after 120 days post-vaccination were mice able to efficiently induce early Mtb growth arrest and maintain long-lasting control of Mtb. This protection correlated with the accumulation of CD4(+) T cells expressing IL-17(+)TNF(+)IL-2(+). In contrast, mice challenged with Mtb 21 days after BCG vaccination exhibited only a mild and transient protection, associated with the accumulation of CD4(+) T cells that were mostly IFN-gamma(+)TNF(+) and to a lesser extent IFN-gamma(+)TNF(+)IL-2(+). These data suggest that the memory response generated by BCG vaccination is functionally distinct depending upon the temporal proximity to BCG vaccination. Understanding how these responses are generated and maintained is critical for the development of novel vaccination strategies against tuberculosis. Copyright 2014 Elsevier Ltd. All rights reserved. | por |
dc.description.sponsorship | We thank the ICVS animal facility personnel for excellent animal husbandry. This work was supported by Fundacao para a Ciencia e Tecnologia, Portugal and cofunded by Programa Operacional Regional do Norte (ON.2-O Novo Norte), Quadro de Referencia Estrategico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) project grants PTDC/SAU-MII/101977/2008, PTDC/BIA-BCM/102776/2008, and from Projeto Estrategico - LA 26 - 2013-2014 (PEst-C/SAU/LA0026/2013). AMC was funded by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health grant AI46530. A.C. received a personal FCT grant SFRH/BPD/3306/2007 and M.S. is an FCT Investigator fellow. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Tuberculosis | por |
dc.subject | BCG vaccination | por |
dc.subject | Multifunctional CD4+ T cells | por |
dc.subject | Effector CD4+ T cells | por |
dc.subject | Memory CD4+ T cells | por |
dc.subject | Memory CD4(+) T | por |
dc.subject | Effector CD4<sup>+</sup> T cells | por |
dc.subject | Memory CD4<sup>+</sup> T cells | por |
dc.subject | Multifunctional CD4<sup>+</sup> T cells | por |
dc.title | BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://ac.els-cdn.com/S0264410X14015370/1-s2.0-S0264410X14015370-main.pdf?_tid=f59d0e6c-86df-11e4-81ee-00000aacb35f&acdnat=1418925898_e0f0714eca7667b9c3f1181d95ef2767 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 85 | por |
oaire.citationEndPage | 91 | por |
oaire.citationIssue | 1 | por |
oaire.citationTitle | Vaccine | por |
oaire.citationVolume | 33 | por |
dc.date.updated | 2015-01-14T18:18:59Z | - |
dc.identifier.doi | 10.1016/j.vaccine.2014.11.013 | por |
dc.identifier.pmid | 25448107 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Vaccine | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cruz a_vaccine 2015 ip.pdf | 1,49 MB | Adobe PDF | Ver/Abrir |