Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32914

TitleLactate transporters in the context of prostate cancer metabolism: what do we know?
Author(s)Gomes, Nelma
Baltazar, Fátima
KeywordsProstate cancer
Monocarboxylate transporters
Cancer metabolism
Therapeutic targets
Issue date2014
PublisherMDPI
JournalInternational Journal of Molecular Sciences
Abstract(s)Metabolic changes during malignant transformation have been noted for many years in tumours. Otto Warburg first reported that cancer cells preferentially rely on glycolysis for energy production, even in the presence of oxygen, leading to the production of high levels of lactate. The crucial role of lactate efflux and exchange within the tumour microenvironment drew attention to monocarboxylate transporters (MCTs). MCTs have been recognized as promising targets in cancer therapy, and their expression was described in a large variety of tumours; however, studies showing how these isoforms contribute to the acquisition of the malignant phenotype are scarce and still unclear regarding prostate cancer. In this review, we focus on the role for MCTs in cell metabolism, supporting the development and progression of prostate cancer, and discuss the exploitation of the metabolic nature of prostate cancer for therapeutic and diagnostic purposes.
TypeArticle
DescriptionLactate Transporters in the Context of Prostate Cancer Metabolism: What Do We Know?
URIhttp://hdl.handle.net/1822/32914
DOI10.3390/ijms151018333
ISSN1422-0067
Publisher versionhttp://www.mdpi.com/1422-0067/15/10/18333
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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