Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32853

TitleSilencing of WNK2 is associated with upregulation of MMP2 and JNK in gliomas
Author(s)Costa, Angela Margarida
Pinto, Filipe
Martinho, Olga
Oliveira, Maria José
Jordan, Peter
Reis, R. M.
KeywordsWNK2
MMP2
JNK
Gliomas
Invasion
Issue date2015
PublisherImpact Journals
JournalOncotarget
Abstract(s)Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter methylation in gliomas. Patients without WNK2 exhibited poor prognosis, and its downregulation was associated with increased glioma cell invasion. Here we showed that MMP2 expression and activity are increased in glioma cell lines that do not express WNK2. Also, WNK2 inhibited JNK, a process associated with decreasing levels of MMP2. Thus, WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential.
TypeArticle
URIhttp://hdl.handle.net/1822/32853
ISSN1949-2553
Publisher versionhttp://www.impactjournals.com/oncotarget/index.php?journal=oncotarget
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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