Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/32522

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dc.contributor.authorAlves, Venâncio Avancini Ferreirapor
dc.contributor.authorPinheiro, Célinepor
dc.contributor.authorSantos, Filipa Moraispor
dc.contributor.authorSilva, Aloisio Felipepor
dc.contributor.authorLongatto Filho, Adhemarpor
dc.contributor.authorBaltazar, Fátimapor
dc.date.accessioned2015-01-08T10:13:15Z-
dc.date.available2015-01-08T10:13:15Z-
dc.date.issued2014-
dc.identifier.issn1007-9327por
dc.identifier.urihttps://hdl.handle.net/1822/32522-
dc.description.abstractAIM: To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC). METHODS: From a total of 5836 autopsies performed at the Pathology Department - University of Sao Paulo School of Medicine Hospital - from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters (MCTs)-1, 2 and 4, CD147 and glucose transporter-1 (GLUT1) was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software (version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's ? (2) test and Fisher's exact test (when n < 5). The threshold for significant P values was established as P < 0.05. RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1 (overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis.por
dc.language.isoengpor
dc.publisherBaishideng Publishing Group Inc.por
dc.rightsopenAccesspor
dc.subjectHepatocellular carcinomapor
dc.subjectMonocarboxylate transporterspor
dc.subjectGlycolysispor
dc.subjectCirrhosispor
dc.subjectGlucose transporter-1por
dc.titleCharacterization of monocarboxylate transporter activity in hepatocellular carcinomapor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155368/?report=readerpor
sdum.publicationstatuspublishedpor
oaire.citationStartPage11780por
oaire.citationEndPage11787por
oaire.citationIssue33por
oaire.citationTitleWorld Journal of Gastroenterologypor
oaire.citationVolume20por
dc.date.updated2014-12-11T18:35:31Z-
dc.identifier.doi10.3748/wjg.v20.i33.11780por
dc.identifier.pmid25206282por
dc.subject.wosScience & Technologypor
sdum.journalWorld Journal of Gastroenterologypor
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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