Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32518

TitleMonocarboxylate transporters as targets and mediators in cancer therapy response
Author(s)Baltazar, Fátima
Pinheiro, Céline
Santos, Filipa Morais
Silva, J. Azevedo
Queirós, Odília
Preto, Ana
Casal, Margarida
KeywordsMonocarboxylate transporters
Cancer therapy
Glycolysis
Molecular targets
Issue date2014
PublisherF Hernandez
JournalHistology and Histopathology
Abstract(s)Monocarboxylate transporters (MCTs) belong to a family of transporters, encoded by the SLC16 gene family, which is presently composed by 14 members, but only MCT1 to 4 have been biochemically characterized. They have important functions in healthy tissues, being involved in the transmembrane transport of lactic acid and other monocarboxylic acids in human cells. One of the recently recognized hallmarks of cancer is altered metabolism, with high rates of glucose consumption and consequent lactate production. To maintain this metabolic phenotype, cancer cells upregulate a series of plasma membrane proteins, including MCTs. MCT1 and MCT4, in particular, play a dual role in the maintenance of the metabolic phenotype of tumour cells. On one hand, they facilitate the efflux of lactate and, on the other hand, they contribute to the preservation of the intracellular pH, by co-transporting a proton. Thus, MCTs are attractive targets in cancer therapy, especially in cancers with a hyper-glycolytic and acid-resistant phenotype. Recent evidence demonstrates that MCTs are involved in cancer cell uptake of chemotherapeutic agents, including 3-bromopyruvate. In this way MCTs can act as "Trojan horses", as their elevated expression in cancer cells can mediate the entry of this chemotherapeutic agent into the cells and selectively kill cancer cells. As a result, MCTs will be mediators of chemotherapeutic response, and their expression can be used as a molecular marker to predict response to chemotherapy.
TypeArticle
DescriptionProofs
URIhttp://hdl.handle.net/1822/32518
ISSN0213-3911
Publisher versionhttp://www.hh.um.es/Forthcoming_original_articles.htm
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
baltazar f_histol histopathol 2014 proof.pdf2,6 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID