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https://hdl.handle.net/1822/32458
Título: | TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients |
Autor(es): | Carvalho, Agostinho De Luca, Antonella Bozza, Silvia Cunha, Cristina D’Angelo, Carmen Moretti, Silvia Perruccio, Katia Iannitti, Rossana G. Fallarino, Francesca Antonio Pierini Latgé, Jean-Paul Velardi, Andrea Aversa, Franco Romani, Luigina |
Palavras-chave: | TLR3 Aspergillosis CD8+ T cells Single nucleotide polymorphism |
Data: | 2012 |
Editora: | American Society of Hematology |
Revista: | Blood |
Resumo(s): | Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections and diseases. CD8+ T cells are present in the human and murine T-cell repertoire to the fungus. However, CD8+ T-cell function in infection and the molecular mechanisms that control their priming and differentiation into effector and memory cells in vivo remain elusive. In the present study, we report that both CD4+ and CD8+ T cells mediate protective memory responses to the fungus contingent on the nature of the fungal vaccine. Mechanistically, class I MHC-restricted, CD8+ memory T cells were activated through TLR3 sensing of fungal RNA by cross-presenting dendritic cells. Genetic deficiency of TLR3 was associated with susceptibility to aspergillosis and concomitant failure to activate memory-protective CD8+ T cells both in mice and in patients receiving stem-cell transplantations. Therefore, TLR3 essentially promotes antifungal memory CD8+ T-cell responses and its deficiency is a novel susceptibility factor for aspergillosis in high-risk patients. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/32458 |
DOI: | 10.1182/blood-2011-06-362582 |
ISSN: | 0006-4971 |
Versão da editora: | http://bloodjournal.hematologylibrary.org/content/119/4/967.long |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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carvalho a_blood 2012 posp.pdf | 303,02 kB | Adobe PDF | Ver/Abrir |